Table 3.

Fine and Gray model on disease free survival (DFS).

Parameter	Univariate analysis			Multivariate analysis
	SHRa	p-value	95% CIb	SHRa	p-value	95% CIb
IDO2
Low	ref	–	–	–
High	1.03	0.937	(0.55–1.91)
IDO1
Low	ref	–	–	–
High	1.44	0.133	(0.89–2.31)
SEX
Female	ref	–	–	–
Male	1.22	0.461	(0.72–2.05)
STAGE
I	ref	–	–	ref	–	–
II–III	1.60	0.044	(1.01–2.54)	1.92	0.006	(1.20–3.09)
HISTOTYPE
Adcc	1.96	0.012	(1.16–3.32)	2.31	0.002	(1.35–3.96)
Sqccd	ref	–	–	ref	–	–
AGE
<68 years	ref	–	–	–
≥68 years	0.72	0.163	(0.45–1.14)
SMOKING
Current smoker	1.91	0.173	(0.75–4.87)	–
Former smoker	1.23	0.663	(0.47–3.17)
Never smoker	ref	–	–
PD–L1
Low	1.06	0.834	(0.60–1.88)	–
High	ref	–	–
TILs DENSITY
Low	ref	–	–	–
High	1.00	0.986	(0.63–1.58)
TILs LOCALIZATION
Intratumoral	1.80	0.563	(0.25–13.15)	–
Peritumoral	2.54	0.380	(0.31–20.34)
Mixed	1.50	0.691	(0.20–11.01)
Absent	ref	–	–

^aSHR: Subdistribution Hazard Ratio.

^bCI: Confidence Interval.

^cAdc: adenocarcinoma.

^dSqcc: squamous cell carcinoma.