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. 2020 May 27;7:267. doi: 10.3389/fvets.2020.00267

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Copyright © 2020 Li, Nguyen, Rosati and Jandrey.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Before-and-after dot plots of light transmission aggregometry from eight cats before and after 7 days of clopidogrel treatment. ADP or thrombin-induced platelet aggregometry was measured as maximum amplitude (%), slope (no unit) and area under the curve (AUC). Thrombin-induced platelet aggregation served as positive control. ADP-induced aggregation, as measured by percent of maximum amplitude (A), slope (B) and AUC (C), was significantly decreased on day 8 (D8) compared to day 0 (D0). In contrast, thrombin did not result in significant changes in all three measurements on light transmission aggregometry. Red dots represent cats that were resistant to clopidogrel therapy. *p < 0.05.