TABLE 1.
Selected clinical laboratory results and daily maximum temperature
| Measure | Reference range | Day 1 (presentation) | Day 3 | Day 4 | Day 5 | Day 7 | Day 10 | Day 11 | Day 12a | Day 14 | Day 16 (discharge) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| WBC (×109/L) | 4.5-11 | 4.1 | 3.18 | 4.17 | 2.86 | 3.07 | 4.3 | 4.31 | 5.39 | 4.85 | 4.39 |
| Neut % | 40-70 | 50.5 | 44.6 | 68.4 | 51.1 | 49.6 | 65 | 66.1 | 65.3 | 68.7 | 54.2 |
| Lymph % | 24-44 | 18.8 | 31.8 | 15.6 | 29.4 | 30.9 | 18.1 | 17.2 | 18 | 13.8 | 22.8 |
| Mono % | 2-11 | 28.5 | 18.9 | 13.2 | 17.1 | 15.6 | 15.1 | 14.4 | 12.8 | 10.5 | 15 |
| Abs lymph | 1.1-4.8 | 0.77 | 1.01 | 0.65 | 0.84 | 0.95 | 0.78 | 0.74 | 0.97 | 0.67 | 1.0 |
| Hgb (g/dL) | 13.9-16.3 | 10.4 | 10.9 | 10.5 | 10.3 | 9.8 | 10.2 | 9.1 | 8.8 | 8.2 | 8.6 |
| Plt (×109/L) | 150-350 | 71 | 54 | 53 | 49 | 61 | 110 | 121 | 134 | 143 | 157 |
| Alb (g/dL) | 3.5-5.3 | 3.7 | 3.8 | 3.5 | 3.5 | 3.3 | 3.4 | 3.3 | 3.2 | 3.4 | 3.4 |
| ALP (U/L) | 30-120 | 194 | 191 | 194 | 184 | 189 | 225 | 205 | 205 | 198 | 250 |
| AST (U/L) | 0-37 | 21 | 22 | 14 | 24 | 31 | 46 | 45 | 47 | 43 | 61 |
| ALT (U/L) | 0-40 | 17 | 16 | 14 | 17 | 15 | 18 | 19 | 18 | 20 | 27 |
| CRP (mg/L) | <0.5 | 11.1 | 14.9 | 6.7 | |||||||
| ESR (mm/H) | 1-20 | >130 | >130 | ||||||||
| Ferritin (mm/H) | 30-400 | 1847 | 1912 | 2188 | |||||||
| LDH (U/L) | 118-273 | 296 | |||||||||
| D-Dimer (mg/L) | 0-0.49 | 1.42 | 1.88 | ||||||||
| IL-6 (pg/mL) | <5 | 39.18 | 122.91 | 203.78 | 3385.06 | ||||||
| T-max (C) | 38.3 | 37.2 | 38.1 | 38.9 | 37.9 | 39.1 | 39.1 | 38.7 | 36.5 | 36.6 |
Abbreviations: Abs Lymph, absolute lymphocytes; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; Hgb, hemoglobin; IL-6, interleukin 6; LDH, lactate dehydrogenase; Lymph, lymphocytes; Mono, monocytes; Neut, neutrophils; Plt, platelet count; T-max, maximum temperature; WBC, white blood cell count.
a
Tocilizumab was administered on day 12.