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The suppressed M. tuberculosis growth caused by apoptotic neutrophils is rescued through MPO inhibition. Apoptotic neutrophils (ApoN) were treated with 500 μM of ABAH (ApoNABAH) for 1 h prior to washing and added to M. tuberculosis (Mtb, MOI = 1) infected (a) and HIV-coinfected (b) macrophagesfor 5 days. The intracellular growth is shown as the mean ± SEM from 5 independent experiments. * p < 0.05, ** p < 0.01, using repeated-measures ANOVA.
