Figure 1.

CCDC61 Is an Evolutionally Conserved Protein Paralogous to SAS6

(A) Domain architectures of the XRCC4 superfamily members. Low complexity regions are drawn by lines.

(B) A phylogenetic tree of CCDC61 orthologs. Accession numbers of the corresponding amino acid sequences are provided in Table S1. Numbers are bootstrap values.

(C) Crystal structure of hCCDC61¹⁻¹⁴³. The structure is presented using a cartoon representation and a rainbow color scheme from the N terminus (N; blue) to the C terminus (C; red). Missing loops are drawn with dotted lines.

(D) Crystal structures of the XRCC4 superfamily members SAS6, XRCC4, XLF, and PAXX (PDB: 2Y3W [van Breugel et al., 2011], 1IK9 [Sibanda et al., 2001], 2QM4 [Li et al., 2008], and 3WTD [Ochi et al., 2015], respectively).

See also Figures S1, S7 and Table S1.