Table 2.
Burden of Rare Variants (MAF < 1%) from BROAD Analysis Enriched in Obese Cases Compared to Controls
| Stage 1 | Stage 2 | Stage 1 + Stage 2 | ||||||
|---|---|---|---|---|---|---|---|---|
| Gene | p Value | Number of Variants/Case Alleles/Control Alleles | OR | p Value | Number of Variants/Case Alleles/Control Alleles | OR | p Value | OR |
| PHIP | 0.0059 | 38/14/29 | 2.11 [1.12–4] | 0.0086 | 22/18/9 | 2.95 [1.33–6.57] | 4.58 × 10−4 | 2.4 [1.5–3.84] |
| DGKI | 0.0134 | 30/18/40 | 1.97 [1.13–3.44] | 0.8910 | 27/14/20 | 1.03 [0.52–2.03] | 0.0998 | 1.35 [0.88–2.07] |
| ZMYM4 | 0.071 | 34/25/70 | 1.56 [0.99–2.47] | 0.4911 | 25/57/89 | 0.94 [0.68–1.31] | 0.4493 | 1.38 [1.06–1.8] |
| ZNF32 | 0.0033 | 6/4/2 | 8.76 [1.6–47.81] | 1.0000 | 3/2/3 | 0.98 [0.16–5.85] | 0.0869 | 3.53 [1.08–11.58] |
Stage 1 included 927 SCOOP cases and 4,057 INTERVAL controls; stage 2 included 1,810 obesity cases and 2,647 Fenland controls.