Fig. 1.

Screenshot from the GRALL website (https://ifm.chimie.unistra.fr/grall). GRALL can be downloaded as a combination of CSV (data) and multi-MOL2 (3D structures) files or accessed online. All compounds are displayed as rows in a table. For each compound, the chemical name, the 2D chemical structure, the isomeric SMILES, the chemical family, the binding site (if known and the level of confidence), the type of activity measurement, the potency against GlyR-α1 and/or -α3, the direction of modulation (i.e. PAM, NAM or absence of modulation) on GlyR-α1 and/or -α3, the DOI of the original publication reporting the functional assays and a link to the 3D structure of the compound in MOL2 format is available. A text-based search engine permits to filter the chemical library. Each column of the database can be directly sorted. Not Available (N.A) is used when the information was not found in the literature