Table 3.

Cox regression analysis of traits associated with OS and PFS

	Univariate HR (95% CI)	Adjusted HR (95% CI)	P-value
OS (n = 127, deaths = 107)
Clinical
Gender is male	0.95 (0.64–1.41)	0.80 (0.53–1.20)	0.280
Race is white	1.69 (0.85–3.37)	2.30 (1.09–4.85)	0.029*
Diagnosis age is below median	0.82 (0.56–1.21)	0.79 (0.53–1.20)	0.273
Radiogenomic
Infiltrative + chr1p35	2.06 (0.98–4.31)	2.06 (0.95–4.43)	0.066
Edema + endothelial	2.07 (0.76–5.67)	4.36 (1.47–12.9)	0.008*
Necrosis + GBM core astrocytes	0.46 (0.14–1.49)	0.11 (0.03–0.45)	0.002*
Necrosis + EMT	1.40 (0.80–2.43)	3.45 (1.75–6.82)	<0.001*
nCET + myogenesis	2.85 (0.89–9.07)	10.7 (2.48–46.5)	0.002*
Necrosis + MYC targets (v2)	0.76 (0.31–1.87)	0.31 (0.10–0.98)	0.045*
Infiltrative + mTORC1 signaling	1.87 (0.76–4.61)	2.38 (0.93–6.10)	0.071
PFS (n = 127, progressions = 88)
Clinical
Gender is male	1.03 (0.65–1.62)	0.80 (0.48–1.34)	0.394
Race is white	1.28 (0.62–2.65)	1.96 (0.89–4.30)	0.094
Diagnosis age is below median	0.98 (0.64–1.50)	1.25 (0.77–2.04)	0.373
Imaging
Tumor was infiltrative	0.92 (0.58–1.45)	1.61 (0.96–2.71)	0.072
Radiogenomic
Infiltrative + chr1p35	2.06 (0.98–4.31)	4.20 (1.89–9.33)	<0.001*
Infiltrative + EMT	2.57 (1.23–5.39)	2.24 (1.27–3.96)	0.006*
Necrosis + MYC targets (v2)	0.21 (0.03–1.49)	0.06 (0.01–0.47)	0.008*
Edema + fetal neurons replicating	1.48 (0.93–2.35)	2.50 (1.44–4.33)	0.001*
Infiltrative + TGF-β signaling	1.51 (0.80–2.86)	1.91 (0.94–3.92)	0.076
Edema + chr18p11	2.22 (0.80–6.15)	5.79 (1.87–18.0)	0.002*
Edema + G2M checkpoint	0.75 (0.36–1.56)	0.46 (0.20–1.05)	0.066
nCET + chr22q13	0.35 (0.09–1.42)	0.36 (0.08–1.60)	0.180
Infiltrative + chr6q27	1.33 (0.76–2.33)	1.79 (0.98–3.30)	0.060
Necrosis + p53 pathway	1.06 (0.39–2.91)	2.44 (0.81–7.39)	0.114

Note: Both OS and PFS adjusted models had P < 0.001 in the likelihood ratio test.

^* P < 0.05.