TABLE 3.

MIC of various compounds against Salmonella Typhimurium SL1344 ramR::aph, Escherichia coli BW25113 marR::aph, Acinetobacter baumannii AB211, and Pseudomonas aeruginosa PAO1 exposed to various compounds alone and in combination with chlorpromazine

Antibiotics	Chlorpromazine concn (fraction of MIC)	MIC (μg/ml)a
		SL1344 ramR::aph	BW25113 marR::aph	AB211	PAO1
Chloramphenicol	None	8	4	64	128
	1/16	4	2	64	64
	1/8	2	2	64	32
	1/4	1	2	32	32
Ciprofloxacin	None	0.03	0.008	128	0.25
	1/16	0.03	0.008	128	0.25
	1/8	0.015	0.008	128	0.25
	1/4	0.008	0.004	128	0.25
Nalidixic acid	None	8	4	512	512
	1/16	4	2	512	128
	1/8	4	2	512	128
	1/4	0.5	2	512	64
Tetracycline	None	4	2	512	32
	1/16	4	1	512	16
	1/8	2	1	256	8
	1/4	1	1	256	8
Norfloxacin	None	0.25	0.03	256	1
	1/16	0.25	0.03	512	1
	1/8	0.25	0.06	512	1
	1/4	0.5	0.06	256	1
Ethidium bromide	None	1,024	128	128	4,096
	1/16	512	128	64	1,024
	1/8	512	64	64	1,024
	1/4	512	64	64	256

^aThe MIC of chlorpromazine was 1,024 μg/ml, 256 μg/ml, 128 μg/ml, and 2,048 μg/ml against SL1344 ramR::aph, BW25113 marR::aph, AB211, and PAO1, respectively. Bold font indicates a ≥2-fold decrease in MIC value in comparison to the antibiotic alone.