FIG 9.

Anti-integrin β1 antibodies protect immunosuppressed mice from invasive pulmonary mucormycosis due to R. delemar. ICR mice (n = 10 [5 female and 5 male]/group with no difference in survival among the two sexes]) were immunosuppressed on days −2, +3, and +8 with cyclophosphamide and cortisone acetate and infected on day 0 intratracheally with R. delemar (actual inhaled inoculum of 2.8 × 10³/mouse). Twenty-four hours postinfection, mice were treated with a single dose of 100 μg of either an isotype-matched IgG (control) or an anti-integrin β1 antibody. P = 0.0006 by log rank test.