Figure 2.

Widespread progressive hippocampal subfield atrophy over time with greater Aβ burden in MCI across datasets. In ADNI dataset, higher level of Aβ correlated to faster decline in volume in all the seven hippocampal subfields, surviving Holm–Bonferroni multiple comparison correction. Similar patterns were observed in the CA1, ML, and subiculum (trend‐wise, p = .051) for the MACC dataset. Data were divided into three approximately equal‐sized groups in terms of the log‐transformed SUVR scores, represented by the solid line (upper tercile), dark gray dotted line (middle tercile), and the light gray dotted line (lower tercile). Hippocampal subfields in orange represented overlapping patterns (a), while those in blue represented distinct patterns between the two datasets (b). Abbreviations: GCL, Granule cell layer of the dentate gyrus; HIP tail, hippocampal tail; MCI, mild cognitive impairment; ML, molecular layer