Figure 4.

Progressive hippocampal subfield atrophy was associated with faster memory decline over time in MACC MCI. For hippocampal subfields that showed progressive atrophy in association with Aβ, faster decline in volume in these subfields correlated to faster memory decline in MCI for the MACC dataset, as well as ADNI dataset (described in text, and not shown in figure). All survived Holm–Bonferroni multiple comparison correction, except a trend‐wise effect in the subiculum (p = .07). Data were divided into three approximately equal‐sized groups in terms of the hippocampal subfields volume, represented by the light gray solid line (upper tercile), dotted line (middle tercile), and the black solid line (lower tercile). Abbreviations: MCI, mild cognitive impairment; ML, molecular layer