Table 1.
Demographic and neuropsychological features of participants included in the cross‐sectional analysis of the ADNI dataset and MACC dataset
| ADNI dataset | MACC dataset | |||||||
|---|---|---|---|---|---|---|---|---|
| NCI | MCI | NCI | MCI | |||||
| (n = 52) | (n = 77) | t/χ 2 | p | (n = 15) | (n = 76) | t/χ 2 | p | |
| Age, M(SD)f | 73.7 (6.7) | 68.6 (6.5) | 4.40 | <.001* | 73.2 (7.4) | 76.0 (5.9) | 1.59 | .12 |
| Male/female | 24/28 | 35/42 | 0.006 | .94 | 8/7 | 37/39 | 0.11 | .74 |
| Handedness, R/Lf | 46/6 | 68/9 | 0.001 | .98 | 15/0 | 74/2 | 0.40 | .53 |
| Ethnicity, H,L/non‐H,L or C/non‐C | 2/50 | 0/77 | 3.01 | .08 | 15/0 | 65/11 | 2.47 | .12 |
| Education, M (SD)e , f | 16.9 (2.4) | 16.5 (2.6) | 0.85 | .40 | 8.0 (4.8) | 8.6 (4.7) | 0.41 | .68 |
| CDR‐SOB, M (SD)a , f | 0.02 (0.1) | 1.3 (0.9) | 12.16 | <.001* | 0.0 (0.0) | 0.8 (0.9) | 7.39 | <.001* |
| MMSE, M (SD)a , f | 29.3 (1.1) | 28.3 (1.6) | 4.37 | <.001* | 28.6 (1.2) | 24.4 (3.6) | 7.17 | .001* |
| Aβ burden, M (SD)b | 0.11 (0.4) | 0.24 (0.4) | 1.61 | .11 | 0.12 (0.3) | 0.40 (0.5) | 2.88 | .007* |
| Aβ burden, rangeb | −0.4~1.1 | −0.4~1.1 | ‐ | ‐ | −0.2~0.9 | −0.2~1.6 | ‐ | ‐ |
| WMH burden, M (SD)b | 0.94 (1.3) | 0.81 (1.1) | 0.61 | .55 | 1.6 (2.3) | 1.8 (1.8) | 0.34 | .73 |
| Dementia convertor, no. (%) | 0 (0) | 17 (22.1) | ‐ | ‐ | 0 (0) | 3 (4.0) | ‐ | ‐ |
| Remitter, no.c (%) | 0 (0) | 0 (0) | ‐ | ‐ | 0 (0) | 1 (1.3) | ‐ | ‐ |
| Follow‐up months, M (SD)d | 48.4 (6.9) | 46.3 (8.2) | 1.58 | .118 | 23.3 (1.8) | 23.7 (2.0) | 0.59 | .556 |
Note: All NCI included in the present study had a MMSE score of ≥26. Groups were compared within each dataset or between datasets on the listed variables, using independent‐samples T test or chi‐square tests where appropriate, with a threshold of p < .05 (*, two‐tailed). We did not compare Aβ, WMH, and ethnicity between datasets due to difference in radiotracer, WMH quantification method and recruited population, respectively.
Abbreviations: C/non‐C, Chinese/non‐Chinese; CDR‐SOB, Clinical Dementia Rating Sum of Boxes score; H,L/non‐H,L, Hispanic or Latino/non‐Hispanic or Latino; L, left; M, mean; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; N, number; NCI, no cognitive impairment; R, right; SD, standard deviation; WMH, white matter hyperintensity.
Six NCI did not have MMSE and CDR‐SOB scores, and CDR‐SOB score was not available for two MCI from the MACC dataset.
Aβ and WMH represented log‐transformed SUVR score with PVC and log‐transformed WMH volume respectively.
This participant remitted from dementia (baseline) to NCI (Year 2), and then deteriorated to MCI during subsequent PET scanning, based on which we included this participant in cross‐sectional analyses but excluded from the longitudinal investigation.
For MACC dataset, a subset of 12 NCI and 45 MCI were included in the longitudinal analyses.
We compared the same group between datasets, with significance being indicated for NCI.
We compared the same group between datasets, with significance being indicated for MCI.