Table 2.
Statistical measures (p‐value and t‐value) for the comparison between regional homogeneity measures (Kendall's coefficient of concordance, KCC) derived from RSNs ROIs for postinfusion and preinfusion of drugs: ketamine and midazolam and the placebo condition. Here, preinfusion means predrug/placebo condition and postinfusion means postdrug/placebo condition
| Network | Regions of interest (ROIs) | Ketamine | Midazolam | Placebo |
|---|---|---|---|---|
| p (t) | p (t) | p (t) | ||
| Auditory network (AN) | Auditory cortices L | 9.9 × 10 −6 (−4.86) a | 0.30 (−1.06) | 0.74 (−0.33) |
| Auditory cortices R | 3.7 × 10 −4 (−3.79) a | 0.36 (−0.92) | 0.72 (−0.36) | |
| Attention network (AttN) | Middle FG L | 3.4 × 10 −6 (−5.16) a | 2.0 × 10 −3 (−3.26) a | 0.52 (−0.64) |
| SPL L | 7.8 × 10 −4 (−3.55) a | 0.08 (−1.78) | 0.39 (−0.87) | |
| Middle FG R | 4.0 × 10 −5 (−4.46) a | 1.4 × 10 −2 (−2.54) | 0.98 (−0.03) | |
| SPL R | 5.0 × 10 −3 (−2.91) | 0.09 (−1.71) | 0.27 (−1.12) | |
| Default mode network (DMN) | PCC/precuneus | 3.3 × 10 −5 (−4.51) a | 2.1 × 10 −4 (−3.97) a | 0.10 (−1.67) |
| Bilateral temporal–parietal region | 2.2 × 10 −5 (−4.63) a | 2.0 × 10 −3 (−3.26) a | 0.14 (−1.50) | |
| vmFC | 2.6 × 10 −6 (−5.23) a | 2.7 × 10 −2 (−2.28) | 0.19 (−1.33) | |
| Executive control network (ECN) | ACC | 4.0 × 10 −8 (−6.35) a | 2.5 × 10 −2 (−2.31) | 0.25 (−1.17) |
| Bilateral medial FG | 3.9 × 10 −8 (−6.36) a | 1.8 × 10 −3 (−3.28) a | 0.20 (−1.31) | |
| Fronto‐parietal network (FPN) | IFG L | 1.7 × 10 −5 (−6.58) a | 1.3 × 10 −2 (−2.57) | 0.24 (−1.18) |
| IPL L | 5.8 × 10 −5 (−4.35) a | 1.8 × 10 −2 (−2.45) | 0.23 (−1.22) | |
| IFG R | 9.9 × 10 −9 (−6.72) a | 1.6 × 10 −2 (−2.48) | 0.26 (−1.14) | |
| IPL R | 1.6 × 10 −5 (−4.72) a | 3.7 × 10 −2 (−2.14) | 0.25 (−1.16) | |
| Salience network (SN) | ACC | 3.1 × 10 −8 (−6.43) a | 0.10 (−1.65) | 0.41 (−0.83) |
| INS L | 1.7 × 10 −8 (−6.59) a | 0.09 (−1.74) | 0.59 (−0.55) | |
| INS R | 7.2 × 10 −5 (−4.29) a | 0.06 (−1.96) | 0.64 (−0.48) | |
| Sensorimotor network (SMN) | Motor area L | 2.5 × 10 −5 (−4.59) a | 0.22 (−1.25) | 0.93 (−0.08) |
| SMA | 1.2 × 10 −2 (−2.59) | 0.99 (0.00) | 0.49 (0.70) | |
| Motor area R | 4.1 × 10 −5 (−4.45) a | 0.78 (−0.28) | 0.28 (−1.09) | |
| Visual network (VN) | Medial visual areas | 2.0 × 10 −3 (−3.25) a | 0.25 (1.18) | 0.29 (1.06) |
| Occipital visual areas | 1.8 × 10 −3 (−3.27) a | 0.98 (−0.03) | 0.87 (0.16) | |
| Lateral visual areas | 2.7 × 10 −3 (−3.14) | 0.65 (−0.46) | 0.70 (−0.38) |
Note: Bolded figures are significant for p < .05. Regions are based on Figure S2.
Abbreviations: ACC, anterior cingulate cortex; FG, frontal gyrus; IFG, inferior frontal gyrus; INS, insula; IPL, inferior parietal lobule; L, left; PCC, posterior cingulate cortex; R, right; SMA, supplementary motor area; SPL, superior parietal lobule; vmFC, ventromedial frontal cortex.
Values those are significant after correction for multiple comparisons.