Table 1.
Review of articles that have performed diffusion MRI analysis on the substantia nigra pars compacta in Parkinson's disease
| Author (year) | Sample size (DTI/NM‐MRI) | ROI placement | ROI image | DTI results of PD in comparison to HC |
|---|---|---|---|---|
| DTI studies with T1/Neuromelanin based SN contrast : | ||||
| Langley et al. (2016) | 20:17/11 (PD: HC /HC) | Manual | NM‐T1, T2w | FA↓, MD↑ for NM‐T1 |
| Menke, Jbabdi, Miller, Matthews, and Zarei (2010) | 10:10 (PD: HC) | Semiautomatic | T1w, DTI tracks | No significance |
| DTI studies with T2w/ T2*w image based SN contrast : | ||||
| Schwarz et al. (2013) | 32:27 (PD: HC) | Manual | T2w | MD↑ |
| Du et al. (2011) | 16:16 (PD: HC) | Semiautomatic | T2w | FA↓, R2*↑ |
| Prakash et.al (2012) | 11:12 (PD: HC) | Manual | T2w | FA asymmetry in SNc subregion in PD |
| Rolheiser et al. (2011) | 14:14 (PD: HC) | Manual | T2w + V1 maps | FA↓, RD↑ |
| Peran et al. (2010) | 30:22 (PD: HC) | Manual | T2*w images | FA↓, R2*↑ |
| Vaillancourt et al. (2009) | 14:14 (PD: HC) | Manual | T2w | FA↓ |
| DTI studies with DTI based SN contrast : | ||||
| Knossalla et al. (2018) | 10:10 (PD: HC) | Manual | FA maps | FA↓ |
| Asymmetry in SNc subregion | ||||
| Loane et al. (2016) | 18:14 (PD:HC) | Manual | FA, MD maps | FA↓, MD↑ |
| Schuff et al (2015) | 67:153 (PD:HC) | Manual | FA maps, T1w | FA↓ in rostral SNc, AD↑, RD |
| No significance | ||||
| Aquino et al. (2014) | 42:20 (PD:HC) | Manual | Axial IR | No significance |
| Zhan et al. (2012) | 12:20 (PD:HC) | Semiautomatic | FA maps | FA↓ |
| Gattellaro et al. (2009) | 10:10 (PD:HC) | Manual | DTI tracks | No significance |
| Chan et al. (2007) | 73:78 (PD:HC) | Manual | FA maps | FA↓ |
Abbreviations: ↑: Increase; ↓: Decrease; DTI: Diffusion Tensor Imaging; FA: Fractional Anisotropy; HC: Healthy Controls; MD: Mean Diffusivity; NM‐MRI: Neuromelanin Magnetic Resonance Imaging; NM‐T1: Neuromelanin sensitive T1; PD: Parkinson's disease; RD: Radial Diffusivity; ROI‐Region Of Interest; SNc: Substantia Nigra pars compacta; T1w: T1 weighted; T2w: T2 weighted.