Table 1.

Demographic and clinical information of participants

	DEP	HC	T tests
Demographic characteristics
Sample size (n)	n = 118	n = 60	n/a
Age (years) (mean/sd)	56.2±16.0	48.6±14.9	0.002
Gender (M/F)	43/71	26/34	0.38
Education degreea (mean/sd)	5.4±1.9	6.3±1.7	0.0013
Handiness (R/L)	111/7	56/4	0.32
Mean frame‐wise displacementb (pre‐ECT)	0.25/0.14	0.17/0.11	2.2e−04
Mean frame‐wise displacementb (post‐ECT)	0.27/0.16	0.17/0.11	1.5e−05
Clinical characteristics
Number of major depressive episodes	6.2±14.4	n/a	n/a
Duration of current depressive episode (months)	23.3±33.5	n/a	n/a
Total number of ECT treatments	11.0±3.4	n/a	n/a
Right unilateral (RUL)/mixed RUL‐bitemporal, and BTc	81/37	n/a	n/a
Pre‐ECT HDRS	25.4±6.1	n/a	n/a
Post‐ECT HDRS	11.5±8.9	n/a	n/a
∆HDRS (pre‐post)	14.0±10.0	n/a	n/a
Responder (%)	64 (54%)	n/a	n/a
Pre‐ECT % recall (verbal declarative memory)	73.7±62.0	n/a	n/a
Post‐ECT % recall (verbal declarative memory)	68.3±30.6	n/a	n/a
∆ “% recall” of verbal declarative memory (pre‐post)	5.9±64.5	n/a	n/a
p value of ∆HDRS	p = 2.8e−66	n/a	n/a
p value of ∆ “% recall”	p = .423	n/a	n/a
Medical characteristics
No medicationd (67%)	79	60	n/a
Antidepressants (33%)	39	0	n/a
SSRI (selective serotonin reuptake inhibitors)	17	0	n/a
SNRI (serotonin–norepinephrine reuptake inhibitors)	17	0	n/a
TCA (tricyclic antidepressants)	4	0	n/a
MAOI (monoamine oxidase inhibitor)	0	0	n/a
Buproprion	1	0	n/a
Antipsychotic (16%)	20	0	n/a

^a“Education degree” details are presented in Supplementary “Education degree” section.

^b“Mean frame‐wise displacement” reflects head motion in functional imaging data.

^cRight unilateral (RUL)/mixed RUL‐bitemporal, and BT denote the final electrode placement of the ECT series.

^d“No medication” denotes tapered off medications before initiation of ECT series (and remained off meds for the duration of the ECT series).