Table 2.
Differences in cortical thickness
Cortical region | L/R | MNI coordinates | Cluster size (mm2) | Number of vertices | Clusterwise p‐value (CWP) | Post hoc group comparisons | ||
---|---|---|---|---|---|---|---|---|
X | Y | Z | ||||||
ADHD‐only versus ADHD+ODD/CD versus TD | ||||||||
Rostral middle frontal | R | 36 | 39 | 10 | 283 | 534 | .41 | |
R | 44 | 23 | 29 | 205 | 353 | .67 | ||
R | 44 | 35 | 26 | 63 | 103 | 1 | ||
Caudal middle frontal | R | 41 | 0 | 34 | 137 | 240 | .9 | |
Parahippocampal | R | 46 | 17 | −39 | 46 | 153 | 1 | |
Supramarginal | L | −43 | −42 | 39 | 49 | 136 | 1 | |
ADHD‐only versus TD | ||||||||
Parahippocampal | R | 17 | −39 | −3 | 80 | 250 | .98 | ADHD‐only>TD |
Supramarginal | L | −43 | −42 | 39 | 117 | 315 | .93 | ADHD‐only>TD |
ADHD+ODD/CD versus TD | ||||||||
Rostral middle frontal* | R | 44 | 23 | 30 | 871 | 1,525 | <.001 | ADHD+ODD/CD≥TD |
R | 36 | 42 | 24 | 101 | 151 | .96 | ADHD+ODD/CD>TD | |
Precentral | R | 42 | 0 | 34 | 158 | 271 | .84 | ADHD+ODD/CD>TD |
Precuneus | R | 10 | −59 | 43 | 107 | 270 | .95 | ADHD+ODD/CD>TD |
Superior parietal | R | 31 | −71 | 19 | 56 | 141 | 1 | ADHD+ODD/CD>TD |
Superior frontal | R | 10 | −3 | 67 | 38 | 77 | 1 | ADHD+ODD/CD>TD |
L | −12 | −5 | 65 | 81 | 190 | .98 | ADHD+ODD/CD>TD | |
L | −19 | 10 | 61 | 28 | 44 | 1 | ADHD+ODD/CD>TD | |
Inferior parietal | L | −34 | −61 | 39 | 51 | 112 | 1 | ADHD+ODD/CD>TD |
ADHD‐only versus ADHD+ODD/CD | ||||||||
Rostral middle frontal* | R | 37 | 40 | 10 | 669 | 1,180 | .01812 | ADHD‐only<ADHD+ODD/CD |
Caudal middle frontal | R | 40 | 0 | 34 | 150 | 267 | .86 | ADHD‐only<ADHD+ODD/CD |
Insula | R | 37 | −18 | −7 | 82 | 235 | .98 | ADHD‐only<ADHD+ODD/CD |
Frontal pole | R | 11 | 58 | −14 | 107 | 133 | .95 | ADHD‐only<ADHD+ODD/CD |
Medial orbito frontal | R | 10 | 33 | −11 | 39 | 93 | 1 | ADHD‐only<ADHD+ODD/CD |
Inferior parietal | R | 34 | 41 | −66 | 34 | 60 | 1 | ADHD‐only<ADHD+ODD/CD |
Medial orbito frontal | L | −12 | 41 | −9 | 85 | 169 | .98 | ADHD‐only<ADHD+ODD/CD |
Isthmus cingulate | L | −7 | −46 | 10 | 38 | 110 | 1 | ADHD‐only<ADHD+ODD/CD |
Note: Smoothing kernel = 15 mm FWHM, cluster‐forming threshold p < .005, Monte Carlo Z simulation with 10,000 iterations; *and underlined = CWP < .05, CWP = clusterwise p‐value. ADHD‐only, attention‐deficit hyperactivity disorder group; ADHD+ODD/CD, comorbid attention‐deficit hyperactivity disorder and conduct disorder/oppositional defiant disorder group; TD, typically developing group.