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. 2019 Dec 14;41(6):1626–1643. doi: 10.1002/hbm.24899

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© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Chronological age and brain age gap for HC and groups with anxiety disorders. Chronological age of the PTSD group is significantly higher than that for the HCs for males (p < .05). Without bias correction, the brain age gap is significantly higher than HCs for the specific phobia group (p < .01) and marginally significantly higher than HCs for the social phobia group (p = .073). Using bias correction without interaction terms, the brain age gap for the PTSD group is significantly higher than HCs (p = .042). When interaction terms of gender and chronological age is included in bias correction, the result is marginally significant (p = .088)