Table 2.
Rs‐fMRI studies reporting aberrant rs‐fMRI connectivity in presymptomatic Huntington's disease individuals compared to healthy controls
| Reference | Presymptomatic Huntington's disease | Healthy controls | Main findings | Analysis | ||||
|---|---|---|---|---|---|---|---|---|
| Sample (% F) | Age (y ± SD) | Education (y ± SD) | Sample (% F) | Age (y ± SD) | Education (y ± SD) | |||
| Visual network | ||||||||
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | No differences | ICA |
| Odish et al., 2015 | 22 (55%) | 43 ± 9 | 4 ± 3a | 18 (61%) | 47 ± 7 | 4 ± 3a | No differences | ICA |
| Coppen et al., 2018 | 21 (48%) | 37 ± 9 | 17 ± 3 | 18 (61%) | 46 ± 11 | 17 ± 2 | No differences | Network of interest |
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | Decreased FC | Network of interest |
| Sensory‐motor network | ||||||||
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | Decreased FC | ICA |
| Unschuld et al., 2012 | 10 (40%) | 44 ± 9 | Na | 10 (60%) | 42 ± 11 | Na | Decreased FC | Seed |
| Koenig et al., 2014 | Low 16 (94%) | 33 ± 9 | 14 ± 2 | 16 (75%) | 43 ± 9 | 16 ± 2 | Increased FC | Seed |
| Medium 16 (69%) | 40 ± 10 | 15 ± 3 | No differences | |||||
| High 16 (88%) | 48 ± 13 | 14 ± 2 | Decreased FC | |||||
| Odish et al., 2015 | 22 (55%) | 43 ± 9 | 4 ± 3a | 18 (61%) | 47 ± 7 | 4 ± 3a | No differences | ICA |
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | No differences | Network of interest |
| Gorges et al., 2017 | 12 (75%) | 36 (27–62) | 14 (9–17) | 22 (32%) | 45 (25–51) | 17 (12–19) | No differences | Seed |
| Cerebellum network | ||||||||
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | No differences | ICA |
| Auditory network | ||||||||
| Odish et al., 2015 | 22 (55%) | 43 ± 9 | 4 ± 3a | 18 (61%) | 47 ± 7 | 4 ± 3a | No differences | ICA |
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | No differences | ICA |
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | No differences | Network of interest |
| Executive network | ||||||||
| Odish et al., 2015 | 22 (55%) | 43 ± 9 | 4 ± 3a | 18 (61%) | 47 ± 7 | 4 ± 3a | No differences | ICA |
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | No differences | ICA |
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | No differences | Network of interest |
| Frontoparietal network | ||||||||
| Odish et al., 2015 | 22 (55%) | 43 ± 9 | 4 ± 3a | 18 (61%) | 47 ± 7 | 4 ± 3a | No differences | ICA |
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | No differences | Network of interest |
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | No differences | ICA |
| Dorsal attention network | ||||||||
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | No differences | Network of interest |
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | Decreased FC | ICA |
| Default mode network | ||||||||
| Dumas et al., 2013 | 28 (61%) | 43 ± 8 | 2–5a | 28 (54%) | 49 ± 9 | 2–5a | No differences | Network of interest |
| Odish et al., 2015 | 22 (55%) | 43 ± 9 | 4 ± 3a | 18 (61%) | 47 ± 7 | 4 ± 3a | No differences | ICA |
| Poudel et al., 2014 | 25 (64%) | 43 ± 9 | Na | 18 (78%) | 46 ± 14 | Na | No differences | ICA |
| Seibert et al., 2012 | 34 (59%) | 41 ± 10 | Na | 22 (68%) | 40 ± 12 | Na | No differences | Seed |
| Salience network | ||||||||
| Mason et al., 2018 | 19 (Na) | 46 ± 12 | Na | 21 (Na) | 42 ± 12 | Na | Reduced coupling activity mainly between SN and other sensory and cognitive networks | Network of interest |
| Subcortical network | ||||||||
| Gorges et al., 2017 | 12 (75%) | 36 (27–62) | 14 (9–17) | 22 (32%) | 45 (25–51) | 17 (12–19) | No differences | Seed |
| Seibert et al., 2012 | 34 (59%) | 41 ± 10 | Na | 22 (68%) | 40 ± 12 | Na | No differences | Seed |
| Regional properties and graph measures | ||||||||
| Gargouri et al., 2016 | 24 (Na) | 39 ± 9 | Na | 18 (50%) | 44 ± 10 | Na | Decreasing hub organization in associative and SMN networks | Graph measures |
| Harrington et al., 2015 | Low 16 (94%) | 33 ± 9 | 14 ± 2 | 16 (75%) | 43 ± 9 | 16 ± 2 | No differences | Graph measures |
| Medium 16 (69%) | 39 ± 10 | 15 ± 3 | Weakened connections within ventral attention centers and frontal areas | |||||
| High 16 (88%) | 47 ± 13 | 14 ± 2 | Weakened connections within frontostriatal network and stronger in ventral attention and parietal areas | |||||
| McColgan, Gregory, et al., 2017 | 64 (45%) | 44 ± 8 | Na | 66 (67%) | 46 ± 8 | Na | Increase connectivity in anterior/frontal and decreased in posterior | Graph measures |
| McColgan, Razi, et al., 2017 | 92 (47%) | 42 ± 10 | Na | 94 (60%) | 48 ± 11 | Na | Greater connectivity within parietal‐DMN regions | Graph measures |
| Sarappa et al., 2017 | 11 (55%) | 38 ± 7 | Na | 40 (55%) | 37 ± 14 | Na | Decreased precuneus ALFF | ALFF |
| Sarappa et al., 2017 | 11 (55%) | 38 ± 7 | Na | 40 (55%) | 37 ± 14 | Na | Decreased cerebellum and subcortical and increased frontotemporal ReHo | ReHo |
Abbreviations: ALFF, amplitude of low frequency fluctuations; F, female; FC, functional connectivity; Na, not available; PCC, posterior cingulate cortex; ReHo, regional homogeneity; SD; standard deviation; Y, years.
a
International Standard Classification of Education.