TABLE 1.
ΔFosB target genes bound in APP and Pilo mice are associated with GO Biological Processes that may influence AD and other diseases with recurrent seizures.
| Category | Select gene ontology | Annotated ΔFosB target genes |
| (GO) Terms | (of 442 shared by APP and Pilo mice) | |
| Excitability and Neurotranmission | Action potential | Dpp6, Dsc3, Fgf12, Hcn1, Kcnc2, Kcnh2, Met, Ryr2 |
| Ion channel activity | Dpp6, Fam155a, Fgf12, Gal, Grm5, Grm7, Gsg1l, Hcn1, Kcnc2, Kcnh2, Kcnq3, Klhl24, Ryr2, Slc1a4, Slc26a7, Trpc6, Vdac1 | |
| Glutamate receptor signaling pathway | Grm5, Grm7, Gsg1l, Klhl24, Plcb1 | |
| Regulation of synaptic plasticity | Adcy8, Bdnf, Ctnnd2, Cx3cr1, Grm5, Mme, Ptpn5/STEP61, Sorcs3, Stau1 | |
| Cellular lipid metabolic process | Abcd3, Chd7, Cyp2c38, Elovl4, Hacd1, Mboat1, Pla2g4c, Plcb1, Prkag2, Sis, St8sia4 | |
| Hormone metabolic process | Bmpr1b, Gal, Iqschfp, Psg18, Schip1, Srd5a2, Ugt1a10, Ugt1a7c | |
| Neurogenesis | Regulation of neurogenesis | Asap1, Aspm, Bdnf, Chd7, Cx3cr1, Cxcl12, Dennd5a, Dlg5, Faim, Grm5, Hey2, Met, Mme, Nbn, Ncoa3, Ndrg4, Opa1, Plxna2, Plxna4, Ptpn5/STEP61, Rgs6, Rheb, Ski, Sox9, Srgap2, Syt17, Tnfrsf21, Trpc6, Vwc2 |
| Cell cycle G2/M phase transition | Cdc25a, Chek1, Hacd1, Nbn, Nek10, Plcb1 | |
| Regulation of stem cell proliferation | Aspm, Bdnf, Cx3cr1, Ncoa3, Nfatc1, Pou3f4 | |
| Notch signaling pathway | Cd46, Fat4, Galnt11, Hey2, Onecut1, Rps19, Sox9, Susd5, Xirp1 | |
| Smoothened signaling pathway | B9d1, Dlg5, Fbxl17, Hhat, Rfx4, Tulp3 | |
| Cellular response to transforming growth factor beta stimulus | Bmpr1b, Cx3cr1, Dnmt1, Ldlrad4, Onecut1, Ski, Sox6, Sox9 | |
| Melatonin receptor activity | Gpr50 | |
| Chromatin Remodeling | Chromatin organization | Asxl2, Cdyl, Chd7, Chek1, Clock, Dmrtc2, Dnmt1, Epc1, H2al1n, Hmgb1, Hmgn3, Mbtd1, Mecom, Mysm1, Ncoa3, Satb1, Selenof, Setd6, Ski, Sox9, Trip12, Usp17le, Yeats2 |
| Chromatin binding | Gmnc, Hmgn3, Satb1, Nfatc1, Mef2a, Dnmt1, Onecut1, Ski, Sox9, Ncoa3 | |
| Histone H3-K9 modification | Chek1, Dmrtc2, Dnmt1, Mecom | |
| Histone acetylation | Cdyl, Chek1, Clock, Epc1, Ncoa3, Yeats2 | |
| Monoubiquitinated histone H2A deubiquitination | Mysm1 | |
| Maintenance of DNA methylation | Dnmt1 | |
| Cellular stress and immunity | Leukocyte activation | Atp11c, Azi2, Camk4, Ccnd3, Cd46, Cd79a, Chd7, Crtc3, Cx3cr1, Cxcl12, Dlg5, Fer, Gab2, Gal, Hmgb1, Lat, Lrfn5, Met, Nbn, Ndrg1, Nfatc1, Nsfl1c, Onecut1, Satb1, Slc22a2, Slc39a10, Tnfrsf21, Tpd52 |
| Myeloid cell differentiation | Asxl2, Camk4, Gab2, Hmgb1, Inhba, Lbr, Nfatc1, Plcb1, Pou3f4, Rhd, Rps19, Slc25a38, Sox6 | |
| Oxidoreductase activity | Cyp2c38, Lbr, Msrb2, Oxr1, Pah, Selenof, Sis, Srd5a2, Txnrd3 | |
| Amino acid transport | Slc7a14 | |
| Autophagosome membrane docking | Stx17 | |
| Amyloid-beta clearance by cellular catabolic process | Mme (neprilysin) |