Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 28;12:1759720X20929443. doi: 10.1177/1759720X20929443

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 3. — Changes in muscle transcript levels after exercise.

(a) Principal component 1 versus principal component 2 from a PCA using all available (genome-wide) muscle mRNA transcripts (n = 18,811), showing two non-overlapping clusters. Green and light-green colours represent post- and pre-exercise healthy women, respectively. Red and pink colours represent post- and pre-strength-training osteoporotic women, respectively; (b) supervised cluster analysis of muscle transcript levels of 18 healthy and 17 osteoporotic women representing 70 samples, before and after strength training. The heat map shows 308 transcripts with differential expression (FDR < 5%) pre versus post-strength training in healthy and/or osteoporotic women identified by repeated-measures ANOVA ignoring disease status. Separate genes whose transcripts show down- (blue) or up-regulation (red) regulation. The colour bar (blue/red) below the heat map represents gene expression standardized to a mean of zero and standard deviation of one of log₂ signal values.

ANOVA, analysis of variance; FDR, false discovery rate; mRNA, messenger ribonucleic acid; OP, osteoporotic; PC, principal component; PCA, principal component analysis.