Table 3.

Training altered thigh muscle transcripts that have corresponding BMD correlated transcripts in bone; correlation between shared iliac bone and pelvic muscle mRNA levels.

A						B
Affymetrix ID	Gene symbol	Gene name	r	p-value	FDR	r	p-value (unadjusted)
229222_at	ACSS3	Acyl-CoA synthetase short-chain family member 3	−0.37	p <0.001	0.100	0.136	0.526
218665_at	FZD4	Frizzled homolog 4 (drosophila)	−0.39	p <0.001	0.078	−0.164	0.444
209576_at	GNAI1	Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1	−0.38	p <0.001	0.088	0.047	0.827
209540_at	IGF1	Insulin-like growth factor 1 (somatomedin C)	−0.41	p <0.001	0.064	0.531	0.007
201505_at	LAMB1	Laminin, beta 1	−0.40	p <0.001	0.064	−0.061	0.777
212274_at	LPIN1	Lipin 1	−0.37	p <0.001	0.092	−0.327	0.119
212636_at	QKI	Quaking homolog, KH domain RNA binding (mouse)	−0.41	p <0.001	0.064	NA
227543_at	RNASEH2C	Ribonuclease H2, subunit C	0.37	p <0.001	0.096	−0.010	0.963
222669_s_at	SBDS	Shwachman-Bodian-Diamond syndrome/Shwachman-Bodian-Diamond syndrome pseudogene	−0.38	p <0.001	0.088	−0.407	0.048
201811_x_at	SH3BP5	SH3-domain binding protein 5 (BTK associated)	−0.44	p < 0.001	0.051	−0.183	0.392
218077_s_at	ZDHHC3	Zinc finger, DHHC-type containing 3	0.37	p < 0.001	0.097	−0.052	0.809
210275_s_at	ZFAND5	Zinc finger, AN1-type domain 5	−0.38	p < 0.001	0.088	0.284	0.179

Part A is extracted from Supplemental Table S5 in Reppe et al.⁹ and includes the bone BMD correlated transcripts [with r, p and false discovery rate (FDR)] having corresponding thigh muscle transcripts that changed upon training (pooled healthy and OP). Part B is based on a subset of healthy (n = 12) or OP (n = 12) iliac bone and pelvic muscle donors presented in Table S1, group C and D, and Supplemental Table S4.

BMD, bone mineral density; FDR, false discovery rate; OP, osteoporosis; RNA, ribonucleic acid; mRNA, messenger RNA.