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. 2020 Jun 3;20:206. doi: 10.1186/s12935-020-01292-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The expression of DSG2 in patient samples was determined by IHC, qRT-PCR and western blotting. a IHC was performed on six pairs of matched CC samples and adjacent nontumor cervical tissue (ANT) samples. Original magnifications: ×200. b Representative results of the IHC of DSG2 in normal samples and early-stage CC samples with and without PLNM. Bar graph shows the percentage of high/low expression of DSG2 in normal samples and early-stage cohort samples. c The mRNA expression of DSG2 was determined by qRT-PCR in 20 NCTs and 20 CC samples (left). The protein expression of DSG2 was determined by western blotting in 3 NCTs and 3 CC samples (right). d The mRNA expression of DSG2 was determined by qRT-PCR in 20 CC samples without PLNM and 20 cervical cancer samples with PLNM (left). The protein expression of DSG2 was determined by western blotting in 3 CC samples without PLNM and 3 CC samples with PLNM (right). e Kaplan–Meier curve for DSG2 and PLNM in early-stage cohort CC patients. DSG2 (−): low expression of DSG2; DSG2 (+): high expression of DSG2. PLNM (−): without PLNM; PLNM (+): with PLNM. f Representative results of the IHC of lymphatic vessel density in CC with high/low expression of DSG2. Original magnifications: 100×