Table 3.
Results of subgroup and meta-regression analyses in the prognostic meta-analysis
| Outcome | Subgroup | Studies | HR (95%CI) | P-value | Heterogeneity (I2) | Pheterogeneity | Meta-regression (P-value) |
|---|---|---|---|---|---|---|---|
| DFS | miRNA classification | P = 0.237 | |||||
| miR-106a | 6 | 1.44(0.88–2.35) | P = 0.151 | 79.9% | P < 0.001 | ||
| miR-106b | 5 | 2.19(1.61–3.00) | P < 0.001 | 0 | P = 0.938 | ||
| Ethnicity | P = 0.322 | ||||||
| Asian | 7 | 2.02(1.60–2.57) | P = 0.569 | 81.7% | P = 0.001 | ||
| Non-Asian | 4 | 1.24(0.59–2.60) | P < 0.001 | 0 | P = 0.507 | ||
| OS | miRNA classification | P = 0.584 | |||||
| miR-106a | 9 | 1.45(1.16–1.80) | P = 0.001 | 48.6% | P = 0.049 | ||
| miR-106b | 2 | 1.57 (0.35–7.08) | P = 0.555 | 80.6% | P = 0.023 | ||
| Ethnicity | P = 0.648 | ||||||
| Asian | 5 | 1.50(1.00–2.24) | P = 0.050 | 79.1% | P = 0.001 | ||
| Non-Asian | 6 | 1.33(0.94–1.88) | P = 0.107 | 56.8% | P = 0.041 |