Table 2.

Reference-free and reference-based estimates of cellular proportions

Cell types	Cell proportions by visit (mean ± SD)				Pearson r with reference-based estimates
	Visit 1	Visit 2	Visit 3	Visit p val	Lymphocytes	Granulocytes
	Reference-free estimates
Cell 1	0.60 ± 0.28	0.74 ± 0.23	0.47 ± 0.32	F2,86 = 6.6, 0.002	− 0.96	0.95
Cell 2	0.13 ± 0.13	0.10 ± 0.10	0.17 ± 0.15	ns	0.51	− 0.47
Cell 3	0.21 ± 0.20	0.12 ± 0.18	0.22 ± 0.19	ns	0.43	− 0.40
Cell 4	0.07 ± 0.18	0.03 ± 0.08	0.14 ± 0.23	F2,86 = 2.7, 0.07	0.77	− 0.81
Granulocytes	0.71 ± 0.14	0.77 ± 0.10	0.64 ± 0.18	F2,86 = 6.1, 0.003
Lymphocytes	0.27 ± 0.12	0.21 ± 0.09	0.33 ± 0.15	F2,86 = 6.6, 0.002