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Mean methylation in the OPRM1 promoter and association with opioid dose and days of use
| MME dosage effect visit 32 | Days of opioid use effect visit 32 | |||||
|---|---|---|---|---|---|---|
| Coef | t val | p (one-tailed) | Coef | t val | p (one-tailed) | |
| Promoter methylation 1 | 0.0002 | 2.16 | 0.02 | 0.003 | 3.40 | 0.001 |
1OPRM1 promoter methylation summarize by averaging the β values for CpG1 to CpG9
2Linear regression at visit 3, one-tailed p value to test hypermethylation with higher cumulative MME or longer duration of use
