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. 2020 Jun 3;7:25. doi: 10.1186/s40779-020-00258-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Network map of DE genes associated with upregulated or downregulated pathways. The network map of DE genes associated with upregulated a or downregulated b pathways was made by Gehpi software. The pathways were showed as pathway ID such as mmu05168. The color and diameter of each circle represent the degree of enrichment of the genes or pathways, the larger diameter, and redder or pinker color indicate the more upregulated or downregulated pathways the gene involved. In addition, the top 10 genes of upregulated c or downregulated d pathways were also identified