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. 2020 Jun 3;8:78. doi: 10.1186/s40478-020-00953-2

Table 2.

Overview of the detected metabolites in cerebrospinal fluid

Parent Drug Metabolite Structure Active / Inactive
imatinib demethylated imatinib = CGP74588 known active
imatinib hydroxylated imatinib = AFN911 known unknown
imatinib N-glucuronidated imatinib unknown unknown
imatinib O-glucuronidated imatinib known unknown
ribociclib demethylated ribociclib = LEQ803 known active
ribociclib hydroxylated LEQ803 unknown unknown
vorinostat succinanilic acid known inactive
vorinostat glucuronidated vorinostat known inactive