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. 2020 Jun 1;21:31. doi: 10.1186/s12865-020-00361-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Correlation of SLAMF7⁺ activated cTfh1 cells with serum IgG4 titer and expression of IL-21 and IL-10 mRNA in Tfh1 subsets in IgG4-RD. a Correlation of serum titers of IgG4 with the number of Th1, activated Tfh, activated Tfh1 and activated Tfh2 cells in IgG4-RD patients. b Correlation of serum titers of IgG4 with the number of SLAMF7⁺ Th1, PD-1⁻ Tfh1, SLAMF7⁻PD-1⁺ Tfh1 and SLAMF7⁺PD-1⁺ Tfh1 cells in IgG4-RD patients. c Comparison of levels of IL-21 and IL-10 mRNA in PD-1⁻ Tfh1 cells, SLAMF7⁻PD-1⁺ Tfh1 cells and SLAMF7⁺PD-1⁺ Tfh1 cells in the peripheral blood of patients with IgG4-RD (n = 11). d Comparison of levels of Bcl-6 and Blimp-1 mRNA in PD-1⁻ Tfh1 cells, SLAMF7⁻PD-1⁺ Tfh1 cells and SLAMF7⁺PD-1⁺ Tfh1 cells in patients with IgG4-RD (n = 7). * indicates p < 0.05, ** indicates p < 0.01