Fig. 5.

High levels of SLAMF7 expression in memory B cells in IgG4-RD and induction of SLAMF7 in memory B cells by Th-associated cytokines. a Comparison of SLAMF7 expression levels in naïve (CD19⁺CD20⁺IgD⁺CD27⁻CD38⁻) and memory (CD19⁺CD20⁺CD27⁺CD38⁻) cells in IgG4-RD patients (n = 13). b Purified memory B cells were cultured with Th-associated cytokines IFN-γ, IL-4, IL-17 and IL-21 along with anti-BCR and CD40 ligand for 72 h. Cells were harvested, then expression levels of SLAMF7 were evaluated by FACS analysis (n = 3)