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. 2020 Jun 1;21:31. doi: 10.1186/s12865-020-00361-0

Fig. 6.

Fig. 6

The hypothetical model in this study. Activated Tfh2 cells promote IgG4 production via interacting with naïve B cells, whereas SLAMF7+ activated Tfh1 cells positive for PD-1 and CD28 do so via interacting with IgG4-memory B cells. Homotypic engagement of SLAMF7 between T and B cells is also depicted. Tfh: follicular helper CD4+ T; SLAMF7: Signaling Lymphocyte Activation Molecule Family member 7; PD-1: Programmed cell death 1; HLA: Human Leukocyte Antigen; BCR: B-cell receptor; TCR: T-cell receptor