Table 2.
Demographic and Clinical Characteristics, Stratified by Incident Hypertension Status (N = 984)
| Characteristic | No HTN(n = 807) | HTN (n = 177) | P value |
|---|---|---|---|
| Male | 603 (74.7) | 137 (77.4) | 0.46 |
| Age (years) | 34.4 ± 9.4 | 38.8 ± 11.2 | < 0.001 |
| BMI (kg/m2) | 21.3 ± 2.8 | 22.1 ± 3.1 | < 0.01 |
| Overweight | 72 (8.9) | 21 (11.9) | 0.23 |
| Obese | 6 (0.7) | 4 (2.3) | NA |
| Han ethnicity | 676 (83.8) | 157 (88.7) | 0.10 |
| Smoking | 200 (24.8) | 38 (21.5) | 0.35 |
| Current alcohol use | 224 (27.8) | 40 (22.6) | 0.16 |
| eGFR (ml/min) | 114 ± 16 | 110 ± 19 | < 0.01 |
| eGFR < 90 (ml/min) | 62 (7.7) | 21 (11.9) | 0.07 |
| Diabetes | 40 (5.0) | 9 (5.1) | 0.95 |
| TC > 5.2 (mmol/l) | 81 (10.0) | 21 (11.9) | 0.48 |
| TG > 1.7 (mmol/l) | 229 (28.4) | 54 (30.5) | 0.59 |
| HDL-c < 1.0 (mmol/l) | 240 (29.7) | 63 (35.6) | 0.17 |
| LDL-c > 4.1 (mmol/l) | 11 (1.4) | 3 (1.7) | NA |
| Dyslipidemia | 397 (49.2) | 100 (56.5) | 0.15 |
| HBs Ag+ | 88 (10.9) | 22 (12.4) | 0.51 |
| HCV Ab+ | 50 (6.2) | 19 (10.7) | 0.03 |
| Route of HIV transmission | < 0.001 | ||
| Heterosexual | 339 (42.0) | 61 (34.5) | |
| Homosexual | 370 (45.8) | 81 (45.8) | |
| Blood transfusion | 23 (2.9) | 22 (12.4) | |
| Others | 75 (9.3) | 13 (7.3) | |
| Years since HIV diagnosis | 1.0 ± 1.7 | 1.1 ± 1.8 | 0.36 |
| Baseline CD4+ cell count (cells/mm3) | 238 ± 125 | 206 ± 124 | < 0.01 |
|
Baseline HIV Viral load (log10 copies/ml) |
4.7 ± 0.7 | 4.7 ± 0.7 | 0.52 |
| Stavudine exposure | 248 (30.7) | 97 (54.8) | < 0.001 |
|
Years of stavudine exposure Zidovudine exposure |
1.2 ± 1.1 316 (39.2) |
0.6 ± 0.7 64 (36.2) |
< 0.0010.46 |
|
Years of zidovudine exposure TDF exposure |
3.3 ± 1.9 470 (58.2) |
1.2 ± 1.1 54 (30.5) |
< 0.001 < 0.001 |
|
Years of TDF exposure Recent CD4+ cell count (cells/mm3) |
1.8 ± 0.7 453 ± 204 |
0.4 ± 0.5 330 ± 162 |
< 0.001 < 0.001 |
| Recent CD4+/CD8+ ratio | 0.7 ± 0.5 | 0.5 ± 0.3 | < 0.001 |
| Recent VL (log10 copies/ml) | 1.5 ± 0.7 | 2.0 ± 0.7 | < 0.001 |
Values are shown as n (%) or mean ± standard deviation
Abbreviations: HTN hypertension; BMI body mass index; NA not available; eGFR, estimated glomerular filtration rate; TC total cholesterol; TG triglycerides; HDL-c high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; HBsAg+, hepatitis B surface antigen; HCV-Ab hepatitis C antibody; HIV human immunodeficiency virus; VL HIV-1 viral load; TDF tenofovir disoproxil fumarate
* Unless stated otherwise, characteristics reported represent baseline characteristics