Table 2.
ACPA Positivity in IPF and Control Cohorts
| Variable | Control Subjects (n = 160) | NJH IPF (n = 80) | BWH IPF (n = 101) | RA-UIP (n = 40) | HP (n = 46) |
|---|---|---|---|---|---|
| IgA-ACPA (+) | 9 (6) | 17 (21)a | 25 (25)a | 21 (53)a | 4 (9) |
| IgG-ACPA (+) | 3 (2) | 6 (8) | 9 (9)b | 29 (73)a | 5 (11)b |
| IgA-ACPA (+) only | 8 (5) | 13 (16)a | 23 (23)a | 2 (5) | 1 (2) |
| IgG-ACPA (+) only | 2 (1) | 2 (3) | 5 (5) | 10 (25)a | 2 (4) |
| IgA-ACPA and IgG-ACPA (+) | 1 (1) | 4 (5)b | 3 (3) | 19 (48)a | 3 (7)b |
Data are presented as No. (%). ACPA = antibodies to citrullinated protein antigens. See Table 1 legend for expansion of other abbreviations.
a
P < .01 comparing each cohort vs population control subjects by using χ2/Fisher exact testing as appropriate.
b
P < .05 comparing each cohort vs population control subjects using χ2/Fisher exact testing as appropriate.