Table 3.
Subject Characteristics Stratified According to ACPA Positivity in IPF Subjects
| Variable | IgA-ACPA Positive (n = 42) | IgA-ACPA Negative (n = 139) | P Valuea | IgG-ACPA Positive (n = 15) | IgG-ACPA Negative (n = 166) | P Valuea |
|---|---|---|---|---|---|---|
| Age, y | 69 ± 7 | 68 ± 7 | .20 | 66 ± 6 | 68 ± 7 | .32 |
| Female sexb | 7 (17) | 34 (25) | .29 | 2 (13) | 39 (24) | .53 |
| Ever smoker | 27 (64) | 87 (64) | .99 | 9 (60) | 105 (65) | .71 |
| FVC, % predictedb | 66 ± 15 | 67 ± 16 | .95 | 63 ± 17 | 66 ± 16 | .59 |
| Dlco, % predictedb | 41 ± 17 | 44 ± 16 | .30 | 39 ± 14 | 43 ± 17 | .47 |
Data are presented as mean ± SD or No. (%). See Table 1 and 2 legends for expansion of abbreviations.
a
P values compare ACPA-positive vs ACPA-negative patients with IPF by using the Student t test, χ2 test, or Fisher exact test as appropriate.
b
BWH patients with IPF missing sex (n = 2), FVC results (n = 31), and Dlco results (n = 52).