Table 3.
Age- and Sex-Adjusted Linear Regressions of Biomarkers and Continuous Clinical Variables, Limited to Subjects With Biomarkers Obtained Within 3 Months of Clinical Tests: n = 191
| Clinical Variable | log NT-proBNP | log Gal3 | log ST2 |
|---|---|---|---|
| RAP, mm Hg | 1.82 (1.25 to 2.38; < .001) | 1.53 (0.29 to 2.77; .01) | 2.58 (1.44 to 3.71; < .001) |
| mPAP, mm Hg | 2.69 (1.41 to 3.97; < .001) | 0.43 (–2.26 to 3.12; .75) | 2.54 (0.01 to 5.06; .049) |
| PAWP, mm Hg | 0.21 (–0.26 to 0.67; .40) | 0.53 (–0.40 to 1.46; .26) | –0.18 (–1.05 to 0.69; .69) |
| PVR, Wood units | 1.18 (0.64 to 1.72; < .001) | 0.50 (–0.64 to 1.64; .39) | 0.55 (0.18 to 0.92; .003) |
| Cardiac output, L/min | –0.19 (–0.36 to –0.02; .03) | –0.003 (–0.34 to 0.33; .98) | –0.27 (–0.59 to 0.04; .09) |
| Cardiac index, L/min/m2 | –0.12 (–0.22 to –0.03; .01) | –0.05 (–0.24 to 0.15; .63) | –0.17 (–0.36 to 0.02; .07) |
| Stroke volume, L | –0.004 (–0.007 to –0.001; .006) | –0.008 (–0.01 to –0.002; .01) | –0.006 (–0.011 to –0.001; .02) |
| PA compliance, mL/mm Hg | –0.17 (–0.26 to –0.08; < .001) | –0.10 (–0.32 to 0.12; .36) | –0.14 (–0.32 to 0.03; .11) |
| RV stroke work, mm Hg × L | –0.07 (–0.18 to 0.04; .21) | –0.32 (–0.005 to –0.07; .01) | –0.20 (–0.40 to 0.01; .05) |
| RV stroke work index, g/m2/beat | –0.001 (–0.002 to 0; .12) | –0.003 (–0.005 to –0.001; .004) | –0.002 (–0.003 to 0; .03) |
| RV power, mm Hg × L/min | –9.74 (–25.39 to 5.92; .22) | 7.44 (–23.2 to 38.09; .63) | –12.06 (–40.24 to 16.12; .40) |
| Heart rate, beats/min | 1.60 (–0.01 to 3.28; .06) | 6.25 (2.58 to 9.92; .001) | 3.88 (0.83 to 6.93; .01) |
| 6MWD, m | –22.43 (–39.85 to –5.02; .01) | –33.77 (–74.66 to 7.12; .10) | –44.76 (–78.03 to –11.50; .009) |