Table 2.
Observed and Fitted Group Assessment of CINV in Each Group
| a. CTCAE assessment of CINV | |||
|---|---|---|---|
| Mean (SD) True acupuncture group (n = 62) |
Sham acupuncture group (n = 58) | P value | |
| Nausea | |||
| Baseline | 0.56 (0.692) | 0.40 (0.528) | 0.244 |
| Day 1 | 0.82 (0.779) | 0.67 (0.636) | 0.326 |
| Day 2 | 0.92 (0.685) | 0.91 (0.779) | 0.921 |
| Day 3 | 0.87 (0.735) | 1.02 (0.761) | 0.288 |
| Day 7 (± 1) | 0.60 (0.689) | 0.71 (0.622) | 0.257 |
| Day 10 (± 1) | 0.37 (0.579) | 0.48 (0.655) | 0.355 |
| Day 14 (± 1) | 0.31 (0.531) | 0.40 (0.591) | 0.388 |
| Day 21 (± 1) | 0.18 (0.426) | 0.39 (0.620) | 0.041* |
| Vomiting | |||
| Baseline | 0.29 (0.555) | 0.16 (0.451) | 0.096 |
| Day 1 | 0.52 (0.695) | 0.30 (0.533) | 0.078 |
| Day 2 | 0.50 (0.741) | 0.60 (0.771) | 0.403 |
| Day 3 | 0.50 (0.647) | 0.57 (0.704) | 0.656 |
| Day 7 (± 1) | 0.29 (0.584) | 0.34 (0.579) | 0.394 |
| Day 10 (± 1) | 0.19 (0.438) | 0.36 (0.693) | 0.177 |
| Day 14 (± 1) | 0.21 (0.484) | 0.31 (0.681) | 0.499 |
| Day 21 (± 1) | 0.10 (0.349) | 0.23 (0.598) | 0.183 |
| b. Completed control rate of CINV | |||
|---|---|---|---|
| No. (%) True acupuncture group (n = 62) |
Sham acupuncture group (n = 58) | P value | |
| Nausea | |||
| Baseline | 34 (54.8) | 36 (62.1) | 0.422 |
| Day 1 | 25 (40.3) | 24 (41.4) | 0.906 |
| Day 2 | 17 (27.4) | 20 (34.5) | 0.402 |
| Day 3 | 21 (33.9) | 16 (27.6) | 0.456 |
| Day 7 (± 1) | 32 (51.6) | 22 (37.9) | 0.132 |
| Day 10 (± 1) | 42 (67.7) | 35 (60.3) | 0.398 |
| Day 14 (± 1) | 45 (72.6) | 38 (65.5) | 0.402 |
| Day 21 (± 1) | 52(83.9) | 39 (67.2) | 0.033* |
| Vomiting | |||
| Baseline | 47 (75.8) | 51 (87.9) | 0.086 |
| Day 1 | 37 (59.7) | 42 (72.4) | 0.142 |
| Day 2 | 39 (62.9) | 32 (55.2) | 0.389 |
| Day 3 | 35 (56.5) | 32 (55.2) | 0.888 |
| Day 7 (± 1) | 48 (77.4) | 40 (69.0) | 0.295 |
| Day 10 (± 1) | 51 (82.3) | 42 (72.4) | 0.197 |
| Day 14 (± 1) | 51 (82.3) | 45 (77.6) | 0.523 |
| Day 21 (± 1) | 57 (91.9) | 48 (82.8) | 0.214 |
| c. Variation of CINV degree evaluated by CTCAE in each group | |||
|---|---|---|---|
| Mean (SD) True acupuncture group (n = 62) |
Sham acupuncture group (n = 58) | P value | |
| Nausea | |||
| Day 1 | 0.258 (0.599) | 0.259 (0.609) | 0.996 |
| Day 2 | 0.355 (0.546) | 0.517 (0.755) | 0.182 |
| Day 3 | 0.306 (0.616) | 0.621 (0.834) | 0.021* |
| Day 7 (± 1) | 0.032 (0.724) | 0.310 (0.654) | 0.030* |
| Day 10 (± 1) | − 0.194 (0.649) | 0.086 (0.539) | 0.011* |
| Day 14 (± 1) | − 0.258 (0.676) | 0.000 (0.375) | 0.011* |
| Day 21 (± 1) | − 0.387 (0.662) | − 0.017 (0.477) | 0.001* |
| Vomiting | |||
| Day 1 | 0.226 (0.556) | 0.138 (0.348) | 0.298 |
| Day 2 | 0.210 (0.631) | 0.448 (0.776) | 0.068 |
| Day 3 | 0.210 (0.604) | 0.414 (0.676) | 0.085 |
| Day 7 (± 1) | 0.000 (0.444) | 0.190 (0.512) | 0.033* |
| Day 10 (± 1) | − 0.097 (0.503) | 0.207 (0.585) | 0.003* |
| Day 14 (± 1) | − 0.081 (0.552) | 0.155 (0.556) | 0.021* |
| Day 21 (± 1) | − 0.194 (0.507) | 0.069 (0.454) | 0.003* |
CINV Chemotherapy Induced Nausea and Vomiting, CTCAE the Common Terminology Criteria for Adverse Events, SD standard deviation
*P values are based on independent-samples t tests comparing differences in between-group means