Table 2.
Subgroup analyses of AF exposure and risk of liver cirrhosis using unadjusted ORs
| Subgroup | Studies, N | OR (95% CI) | p value | Tests for heterogeneity | ||
|---|---|---|---|---|---|---|
| Q | p | I2 | ||||
| All studies | 8 | 3.35 (2.74,4.10) | 0.000 | 59.58 | 0.000 | 88.3% |
| Study design | ||||||
| Case-control studies | 7 | 3.67 (2.93,4.59) | 0.000 | 56.38 | 0.000 | 89.4% |
| Nested case-control studies | 1 | 2.29 (1.44,3.64) | 0.000 | 0.00 | – | – |
| Method of AF exposure assessment | ||||||
| Serum AF-albumin adduct level | 3 | 4.89 (3.77, 6.35) | 0.000 | 17.83 | 0.000 | 88.8% |
| 249ser TP53mutation | 3 | 4.3 (2.55,7.26) | 0.000 | 0.30 | 0.863 | 0.0% |
| Groundnut consumption | 2 | 1.15 (0.76,1.72) | 0.51 | 5.68 | 0.017 | 82.4% |
| Geographic location | ||||||
| Asia | 4 | 4.85 (3.75,6.26) | 0.000 | 18.01 | 0.000 | 83.3% |
| Africa | 4 | 1.84 (1.32,2.55) | 0.000 | 20.75 | 0.000 | 85.5% |
AF Aflatoxin, OR Odds ratio, CI Confidence interval