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. 2020 Jun 3;20:513. doi: 10.1186/s12885-020-07001-1

Table 2.

Correlation between postoperative pathology and clinicopathological features

Parameters Postoperative pathology p value
DCIS only
(n = 70)
Invasive ductal carcinoma
(n = 48)
Age at operation (years old)
  ≤ 60 50 (71.4%) 33 (68.8%)
  > 60 20 (28.6%) 15 (31.3%) 0.754
Symptoms
 Asymptomatic 30 (42.9%) 12 (25.0%)
 Symptomatic 40 (57.1%) 36 (75.0%) 0.044
Palpability
 Impalpabe 24 (34.3%) 9 (18.8%)
 Palpable 46 (65.7%) 39 (81.3%) 0.065
Tumor size (mm)
  ≤ 20.0 48 (68.6%) 23 (47.9%)
  > 20.0 22 (31.4%) 25 (52.1%) 0.024
Biopsy device
 Core needle biopsy 32 (45.7%) 35 (72.9%)
 Vacuum-assisted biopsy 38 (54.3%) 13 (27.1%) 0.003
Estrogen receptor
 Negative 9 (12.9%) 13 (27.1%)
 Positive 61 (87.1%) 35 (72.9%) 0.051
Progesterone receptor
 Negative 18 (25.7%) 19 (39.6%)
 Positive 52 (74.3%) 29 (60.4%) 0.111
HER2
  ≤ 2 63 (90.0%) 38 (79.2%)
 3 7 (10.0%) 10 (20.8%) 0.100
Ki67
  ≤ 14% 60 (85.7%) 38 (79.2%)
  > 14% 10 (14.3%) 10 (20.8%) 0.352
Grade of DCIS
 Low, intermediate 63 (90.0%) 35 (72.9%)
 High 7 (10.0%) 13 (27.1%) 0.015
Comedonecrosis
 Absence 37 (52.9%) 17 (35.4%)
Presence 33 (47.1%) 31 (64.6%) 0.061
Intraductal calcification
 Absence 62 (88.6%) 37 (77.1%)
 Presence 8 (11.4%) 11 (22.9%) 0.098
Lymphoid infiltrate
 Negative, mild 56 (80.0%) 27 (56.3%)
 Moderate, severe 14 (20.0%) 21 (43.8%) 0.006
Platelets–lymphocyte ratio
 Low 50 (71.4%) 24 (50.0%)
 High 20 (28.6%) 24 (50.0%) 0.018
LDH
  ≤ ULN 63 (90.0%) 42 (87.5%)
  > ULN 7 (10.0%) 6 (12.5%) 0.670
CEA
  ≤ ULN 66 (94.3%) 45 (93.8%)
  > ULN 4 (5.7%) 4 (5.7%) 0.904
CA15–3
  ≤ ULN 69 (98.6%) 46 (95.8%)
  > ULN 1 (1.4%) 2 (4.2%) 0.353

DCIS Ductal carcinoma in situ, HER2 Human epidermal growth factor receptor 2, LDH Lactate dehydrogenease, ULN Upper limit of normal, CEA Carcinoembryonic antigen