Table 2.
Genotype and allele frequencies of the analyzed polymorphisms of the OPG gene for OTSC and healthy control subjects
| SNP ID | Genotype Frequency (%) |
X2-Test p < 0.05 |
OR (95% CI) | Allele Frequency (%) |
p-value | ||||
|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | Cases | Controls | ||||||
|
rs2228568 (c.768A > G) |
A/A | 78.6 | 76 | 0.483 | 0.90 | ||||
| A/G | 18.1 | 22.4 | A | 87.6 | 87.2 | ||||
| G/G | 3.3 | 1.6 | G | 12.4 | 12.8 | ||||
|
rs7844539 (c.817 + 8A > C) |
A/A | 78.6 | 76 | 0.483 | 0.90 | ||||
| A/C | 18.1 | 22.4 | A | 87.6 | 87.2 | ||||
| C/C | 3.3 | 1.6 | C | 12.4 | 12.8 | ||||
|
rs3102734 (c.30 + 15C > T) |
C/C | 92.9 | 84.2 | 0.013 | Reference | 0.014 | |||
| C/T | 6 | 14.1 |
0.379 (0.04–3.613) |
C | 95.9 | 91.2 | |||
| T/T | 1.1 | 1.7 |
0.287 (0.116–0.708) |
T | 4.1 | 8.8 | |||
|
rs2073618 (c.9C > G) |
C/C | 14.8 | 19.9 | 0.007 | Reference | 0.0041 | |||
| C/G | 30.1 | 40.4 |
0.494 (0.235–1.037) |
C | 29.8 | 40.1 | |||
| G/G | 55.1 | 39.8 |
0.482 (0.265–0.876) |
G | 70.2 | 59.9 | |||
SNP Single-nucleotide polymorphism; OR Odds ratio; CI Confidence interval. Statistical significance were not obtained with otosclerotic and control samples in the rs2228568 and rs7844539 polymorphisms, while significant values were detected for the rs3102734 and rs2073618 polymorphisms (in bold). Besides, both SNPs revealed an allelic association with OTSC