Table 4.
OPG haplotype structure and frequencies
| Haplotype frequency | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Overall | Females | Males | |||||||
| Haplotype | Cases | Controls | p-value | Cases | Controls | p-value | Cases | Controls | p-value |
| A-A-C-G | 62.19 | 48.59 | 0.0135 | 63.83 | 37.06 | 0.0001 | 57.65 | 68.42 | 0.2658 |
| A-A-C-C | 22.28 | 33.5 | 0.0209 | 21.32 | 42.54 | 0.0004 | 24.89 | 18.42 | 0.4373 |
| A-A-T-G | 4.39 | 6.42 | 0.4015 | 4.84 | 8.36 | 0.2638 | 29.8 | 5.26 | 0.5453 |
| C-G-C-C | 5.76 | 3.2 | 0.2958 | 5.49 | 3.76 | 0.5611 | 6.69 | 2.63 | 0.3632 |
| C-G-T-G | 0.69 | 1.19 | 0.6137 | 0.62 | 1.83 | 0.3465 | 0.97 | 0 | 0.5439 |
Four SNPs in the following order: rs2228568, rs7844539, rs3102734, rs2073618, were used to analyze the haplotypes within the OPG gene in cases and controls. P-values are based on 10,000 permutations. Two significant haplotypes were detected: A-A-C-G and A-A-C-C (values are indicated in bold)