Table 6.

Frequencies of common allele combinations of OPG, TGFβ1, RELN and Chromosome 11 SNPs in OTSC cases and controls

	Frequency
	Over all			Females			Males
Allele combinations	Cases	Controls	p-value	Cases	Controls	p-value	Cases	Controls	p-value
G-C-A-C-A-G	0.2703	0.2322	0.4113	0.2715	0.2367	0.5416	0.1387	0.3055	0.0349
G-C-G-C-A-G	0.1923	0.1662	0.5235	0.1888	0.1735	0.7609	0.2541	0.1662	0.2594
C-C-A-C-A-G	0.0669	0.1869	0.0004	0.0476	0.1732	0.0008	0.2363	0.1019	0.0609
C-C-A-T-G-G	0.1215	0.0533	0.0281	0.1077	0.0779	0.4392	0.0179	0.1569	0.0094

The allele combination analysis of the six SNPs in the following order: rs2073618, rs1800472, rs39335, rs39350, rs39374 and rs494252 revealed significant differences between cases and controls with sex-specific associations in C-C-A-C-A-G for females and G-C-A-C-A-G and C-C-A-T-G-G for males