Table 1.
Author year Country | Species, Strain, Gender | No. of treated animals | No. of controls | Sepsis model | MSC source, Compatibility | MSC Dose | Time of delivery post-sepsis induction | MSC route | Control |
---|---|---|---|---|---|---|---|---|---|
Gonzalez-Rey et al. (2009)A Spain [10] | Mouse BALB/c, NR | 18 | 10 | CLP | Adipose, Xenogenic or Allogeneic | 1.0×106 | 4 hours | IP | DMEM |
Gonzalez-Rey et al. (2009)B Spain | Mouse BALB/c, NR | 20 | 10 | LPS (i.p.) | Adipose, Xenogenic or Allogeneic | 1.0 × 106 or 3.0 × 105 | 0.5 hours | IP | DMEM |
Nemeth et al. (2009) United States [11] | Mouse C57BL/6, M | 90 | 45 | CLP | Bone marrow, Allogeneic | 1.0×106 | 0 or 1 hour | IV | PBS |
Bi et al. (2010) China [12] | Mouse C57BL/6, NR | 10 | 10 | CLP | Bone marrow, Xenogenic | 1.0×106 | 1 1 hours | IV | PBS |
Mei et al. (2010)A Canada [13] | Mouse C57BL/6J, F | 29 | 29 | CLP | Bone marrow, Syngeneic | 2.5×105 | 6 hours | IV | NS |
Mei et al. (2010)B Canada | Mouse C57BL/6J, F | 15 | 20 | CLP | Bone marrow, Syngeneic | 2.5×105 | 6 hours | IV | NS |
Liang et al. (2011) China [14] | Rat Wistar, F | 15 | 15 | LPS (i.v.) | Bone marrow, Syngeneic | 1.0×106 | 2 hours | IV | NS |
Chang et al. (2012) China [15] | Rat SPD, M | 16 | 16 | CLP | Adipose, Autologous | 3× 1.2×106 | 0.5, 6 then 18 | IP | NS |
Krasnodembskaya et al. (2012) USA [16] | Mouse C57BL/6J, M | 34 | 69 | P. aeruginosa (i.p.) | Bone marrow, Xenogenic | 1.0×106 | 1 hour | IV | PBS |
Li et al. (2012) China [17] | Rat SPD, M | 20 | 40 | LPS (i.p.) | Umbilical cord, Xenogenic | 5.0×105 | 1 hour | IV | NS |
Hall et al. (2013) USA [18] | Mouse BALB/c, M | 26 | 35 | CLP | Bone marrow, Syngeneic | 1× 5.0 ×105 + 2 ×2.5× 105 | 2 then 24 then 48 hours | IV | PBS |
Zhao et al. (2013) China [19] | Rat SPD, F | 24 | 27 | LPS (i.v.) | Bone marrow, Syngeneic | 2.5×106 | 2 hours | IV | NS |
Chao et al. (2014) Taiwan [20] | Rat Wistar, M | 20 | 10 | CLP | Bone Marrow or Umbilical Cord, Xenogenic | 5.0×106 | 4 hours | IV | PBS |
Kim et al. (2014) Canada [21] | Mouse C57BL/6, M | 73 | 66 | SEB+ (i.p) | Bone marrow, Syngeneic | 2.5×105 | 3 hours | IV | PBS |
Luo et al. (2014) China [22] | Mouse C57Bl/6, M | 20 | 20 | CLP | Bone marrow, Syngeneic | 1.0×106 | 3 hours | IV | NS |
Pedrazza et al. (2014) Brazil [23] | Mouse C57BL/6, M | 15 | 15 | E. coli (i.p.) | Adipose, Syngeneic | 1.0×106 | 0 | IV | PBS |
Sepulveda et al. (2014) Spain [24] | Mouse BALB/c, M | 30 | 10 | LPS (i.p.) | Bone Marrow, Xenogenic | 1.0×106 | 0.5 hour | IP | PBS |
Zhao et al. (2014) China [25] | Mouse C57BL/6, M | 12 | 12 | CLP | Umbilical cord, Xenogenic | 1.0×106 | 1 hour | IV | NS |
Zhou et al. (2014) China [26] | Mouse NOD SCID, M | 7 | 7 | LPS+ (i.p.) | Umbilical Cord, Xenogenic | 2.0×106 | 6 hours | IV | No treatment |
Yang et al. (2015) China [28] | Mouse NOD SCID, M | 10 | 10 | LPS+ (i.p.) | Umbilical cord, Xenogenic | 5.0×105 | 0 | IV | DMEM |
Francisca et al.(2015) Chile [27] | Mouse C57BL6/j, NR | 21 | 16 | CLP | menstrual fluid, Xenogenic | 7.5 × 105 | 3 hours | IV/IP | NS |
Hao Ou et al.(2015)A China [29] | Mouse SPF BALB/c, NR | 7 | 14 | LPS | Adipose, Allogeneic | 1.0 × 107 | 5 mins | IV | NS |
Hao Ou et al.(2015)B China | Mouse SPF BALB/c, NR | 9 | 14 | LPS | Bone marrow, Allogeneic | 1.0 × 107 | 5 mins | IV | NS |
Pei-Hsun Sung et al.(2017) Taiwan, China [30] | Rats SPD, M | 16 | 16 | CLP | Adipose, Autologous | 1.2×106 | 3 hours | IV | NS |
Xujing Liang et al.(2019) China [33] | Rats SPD, M | 10 | 10 | CLP | Umbilical cord, Xenogenic | 2.5×106 | 0 | IV | PBS |
Xian-Fei Ding et al.(2019) China [31] | Rats SPD, M | 30 | 30 | CLP | Adipose, Allogeneic | 1.0×106 | 1 hour | IP | NS |
Mirjana Jerkic et al.(2019)A Canada [32] | Rats SPD, M | 12 | 15 | E. coli | Umbilical cord, Xenogenic | 1.0× 107 | 1 hour | IV | PBS |
Mirjana Jerkic et al.(2019)B Canada | Rats SPD, M | 11 | 15 | E. coli | IL-10 UC-MSCs, Xenogenic | 1.0 × 107 | 1 hour | IV | PBS |
Huoyan Liang et al.(2019) China [41] | Rats SPD, M | 20 | 20 | CLP | Adipose, Allogeneic | 1.0×106 | 1 hour | IP | NS |
CLP Cecal ligation and puncture, DMEM Dulbecco’s modified Eagle’s medium, i.p. Intraperitoneal, i.v. Intravenous, LPS Lipopolysaccharide, NR Not reported, NS Normal saline, PBS Phosphate buffered saline, SEB Staphylococcal enterotoxin B, SPD Sprague Dawley, M Male, F Female, E. coli Escherichia coli, P. aeruginosa Pseudomonas aeruginosa