Table 2.

SYRCLE Risk of Bias Assessment for included studies

Author (Year)	Random sequence generation?	Groups similar at baseline?	Allocation concealed?	Animals randomly housed?	Blinding of caregivers and/or examiners?	Random selection for outcome assessment?	Blinding of outcome assessor?	Incomplete outcome data addressed?	Free from selective outcome reporting?	Free from other bias?
Gonzalez-Rey et al.(2009) [10]	U	U	U	U	U	U	U	L	L	H
Nemeth et al. (2009) [11]	U	U	U	U	U	U	U	L	L	L
Bi et al. (2010) [12]	U	U	U	U	U	U	U	H	L	L
Mei et al. (2010) [13]	U	U	U	U	U	U	U	L	L	H
Liang et al. (2011) [14]	U	U	U	U	U	U	U	U	L	L
Chang et al. (2012) [15]	U	U	U	U	U	U	U	U	L	H
Krasnodembskaya et al.(2012) [16]	U	U	U	U	U	U	U	U	L	L
Li et al. (2012) [17]	U	U	U	U	U	U	U	U	L	L
Hall et al. (2013) [18]	U	U	U	U	U	U	U	U	L	L
Zhao et al. (2013) [19]	U	U	U	U	U	U	U	U	L	L
Chao et al. (2014) [20]	U	U	U	U	U	U	U	U	L	L
Kim et al. (2014) [21]	U	U	U	U	U	U	H	U	L	L
Luo et al. (2014) [22]	U	U	U	U	U	U	U	U	L	L
Pedrazza et al. (2014) [23]	U	U	U	U	U	U	U	U	L	L
Sepulveda 2014 [24]	U	U	U	U	U	U	U	U	L	L
Zhao et al. (2014) [25]	U	U	U	U	U	U	U	U	L	L
Zhou et al. (2014) [26]	U	U	U	U	U	U	U	H	L	L
Yang et al. (2015) [28]	U	U	U	U	U	U	U	U	L	L
Francisca et al. (2015) [27]	U	U	U	U	U	U	U	L	L	L
Hao Ou et al. (2015) [29]	U	U	U	U	U	U	U	L	L	L
Pei-Hsun Sung et al. (2017) [30]	U	U	U	U	U	U	U	L	L	L
Xujing Liang et al. (2019) [33]	U	U	U	U	U	U	U	L	L	L
Xian-Fei Ding et al. (2019) [31]	U	U	U	U	U	U	U	L	L	L
Mirjana Jerkic et al. (2019) [32]	U	U	U	U	U	U	U	U	U	U
Huoyan Liang et al. (2019) [41]	U	U	U	U	U	U	U	L	L	L

H High risk of bias, L Low risk of bias, U Unclear risk of bias