Table 1.

Main genes and cellular components/processes implicated in the pathogenesis of ALS and FTD

RNA metabolism	TARDBP, FUS, hnRNPA1, hnRNPA2B1, MATR3, ATXN2, TAF15, SETX, EWSR1, ELP3, ANG
Protein trafficking and Proteostasis	C9ORF72, CHMP2B, FIG 4, TBK1, UBQLN2, SQSTM1, SIGMAR1, OPTN, VCP, ALS2, VAPB
DNA repair	EWSR1, FUS, SETX, TAF15, TARDBP
Mitochondria and Oxidative stress:	SOD1, CHCHD10, C19ORF12
Immune response/Inflammation:	GRN, TREM2, TYROBP
Stress granule assembly	ATXN2, C9ORF72, MAPT
Glia and Neurons metabolism	GRN, SIGMAR1, SOD1, TREM2, TYROBP
Vacuolar transport	C9ORF72, CHMP2B, GRN, TMEM106B, VCP, OPTN, UNC13A
Axo-dendritic transport	KIF5A, MAPT, SPG11