Table 2.
Organ involvement and histological evidence indicating subjects with evidence of noncaseating granulomas
| Characteristics | Organ Involvement per WASOG Tool | Histological Evidence | |||
|---|---|---|---|---|---|
| n/187 | % | 95% CI | n/total | % | |
| Lung | 184 | 98.4 | 95.4–99.7 | 158/184 | 85.9 |
| Skin | 27 | 14.4 | 9.7–20.3 | 22/27 | 81.5 |
| Liver | 33 | 17.6 | 12.5–23.9 | 12/33 | 36.4 |
| Eye | 39 | 20.9 | 15.3–27.4 | 5/39 | 12.8 |
| Spleen | 39 | 20.9 | 15.3–27.4 | 2/39 | 5.1 |
| Salivary Gland | 4 | 2.1 | 0.6–5.4 | 1/4 | 25.0 |
| ENT | 4 | 2.1 | 0.6–5.4 | 3/4 | 75.0 |
| Calcium-VitD | 10 | 5.3 | 2.6–9.6 | 0/10a | 0.0 |
| Bone-Joint | 18b | 9.6 | 5.8–14.8 | 3/18 | 16.7 |
| Bone Marrow | 6 | 3.2 | 1.2–6.9 | 4/6 | 66.7 |
| Muscle | 2 | 1.1 | 0.1–3.8 | 1/2 | 50.0 |
| Extra-Thoracic Lymph Node | 64 | 34.2 | 27.5–41.5 | 18/64 | 28.1 |
| Kidney | 2 | 1.1 | 0.1–3.8 | 2/2 | 100.0 |
| Nervous System | 14 | 7.5 | 4.1–12.2 | 1/14c | 7.1 |
| Cardiac | 20 | 10.7 | 6.7–16.0 | 3/20 | 15.0 |
| Other Organs | 9 | 4.8 | 2.2–8.9 | 6/9 | 66.7 |
| Testis | 3 | 1.6 | 0.3–4.6 | 2/3 | 66.7 |
| Large intestine | 1 | 0.5 | 0.0–2.9 | 1/1 | 100.0 |
| Stomach | 2 | 1.1 | 0.1–3.8 | 2/2 | 100.0 |
| Thyroid | 2 | 1.1 | 0.1–3.8 | 0/2 | 0.0 |
| Appendix | 1 | 0.5 | 0.0–2.9 | 1/1 | 100.0 |
a10 subjects with evidence of calcium stones by stone analysis for calcium-vitD involvement
b4 subjects with arthralgia associated with Lofgren’s syndrome was included for bone-joint involvement
c3 subjects with evidence of small fiber neuropathy by skin biopsy for nervous system involvement