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. 2020 Jun 3;8:75. doi: 10.1186/s40478-020-00945-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Intranuclear inclusions in extra-skeletal muscle organs. a-c Sympathetic ganglia. Two eosinophilic neuronal intranuclear inclusions with surrounding halos are evident on HE staining (a). The inclusions are positive for ubiquitin (b). Numerous inclusions are revealed by p62-immunohistochemistry (c). d A p62-positive neuronal intranuclear inclusion in the transentorhinal cortex. e A p62-positive intranuclear inclusion (green) in a GFAP-positive astrocyte (red) in the temporal cortex. Double-labeling immunofluorescence. f, g Ultrastructure of a sympathetic ganglion neuron containing an intranuclear inclusion (f, arrow). The inclusion is composed of fine filamentous structures without limiting membranes. Scale bar: a, b = 40 μm; c = 150 μm; d, e = 25 μm; f = 5 μm; g = 750 nm