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. 2020 Jun 3;39:101. doi: 10.1186/s13046-020-01598-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Circ_0043800 was up-regulated in HB tissues and cells. a qRT-PCR was applied to measure the expression level of 10 candidate circRNAs in HepG2 and HuH-6 cells (they were referred as HB cells in our study for convenience) compared to control cells of THLE-3. Student’s t-test. b qRT-PCR detected relative expression of circ_0043800 and circ_0043804 in HB tissues and adjacent non-tumor tissues. Student’s t-test. c Schematic diagram of the splicing pattern of circ_0043800 and Sanger sequencing of circ_0043800. d The existence of circ-STAT3 in HB cells was validated by qRT-PCR. e Relative expression of circ-STAT3 and STAT3 in HB cells under the treatment of RNaseR. Student’s t-test. f-g FISH (scale bar: 10 μm) and subcellular fraction assay revealed subcellular location of circ-STAT3. ^**P < 0.01. The symbol “n.s.” indicates no significance