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. 2020 Jun 3;39:101. doi: 10.1186/s13046-020-01598-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circ-STAT3 promoted HB cell proliferation, invasion, migration and stemness characteristic. a qRT-PCR verified depletion efficiency of circ-STAT3. One-way ANOVA. b-c EdU (scale bar: 100 μm) and colony formation assay detected proliferation ability of HB cells by knockdown of circ-STAT3. One-way ANOVA. d-e Transwell (scale bar: 200 μm) and wound healing assay (scale bar: 200 μm) examined invasion and migration ability of cells transfected with sh-circ-STAT3#2/3. One-way ANOVA. f Sphere formation assay (scale bar: 200 μm) revealed sphere formation efficiency of circ-STAT3 silenced cells. One-way ANOVA. g-h qRT-PCR and western blot detected expression of stemness biomarkers in circ-STAT3 silenced cells. One-way ANOVA. ^**P < 0.01.