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. 2020 Jun 3;39:101. doi: 10.1186/s13046-020-01598-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — STAT3 partially rescued the effects of circ-STAT3 on cell biological functions. a Overexpression efficiency of STAT3 was assessed via qRT-PCR. Student’s t-test. b-c EdU (scale bar: 100 μm) and colony formation assay detected influence of STAT3 overexpression on circ-STAT3 depletion-mediated proliferation ability of HB cells. One-way ANOVA. d-e Transwell (scale bar: 200 μm) and wound healing assay (scale bar: 200 μm) examined cell invasion and migration ability in sh-NC, sh-circ-STAT3#2 and sh-circ-STAT3#2+ pcDNA3.1/STAT3 group. One-way ANOVA. f-h Sphere formation assay (scale bar: 200 μm), qRT-PCR and western blot analysis revealed cell stemness in sh-NC, sh-circ-STAT3#2 and sh-circ-STAT3#2+ pcDNA3.1/STAT3 group. One-way ANOVA. ^*P < 0.05, ^**P < 0.01