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Molecular mechanism of circRNAs. A circRNAs sponge miRNA to release mRNA and regulate transcription indirectly; B circRNAs with RNA-binding protein-binding motifs sponge or decoy RNA binding proteins (RBPs) to regulate transcription; C circRNAs serve as a scaffold for proteins; D circRNAs with internal ribosome entry sites (IRESs) can be translated into peptides or proteins, driven by m6A; E circRNAs regulate transcription of parental genes
